DNA Sequencing Activity

This graph represents how alike Abby, Bob, and Carol are alike to Norm, or the Normal DNA.

• Abby only had one difference from Norm. Norm had GAG, but Abby had GTG, otherwise known as a point mutation. This also changed the protein from Glu to Val. This could lead to disease, or other problems because of this change. 
• Bob also only had on difference from Norm. Norm had AAG, but Bob had TAG, another point mutation. This also changed the protein from Lys, to the signal that the protein stops, also read as "stop!" Clever huh? This change causes the protein to become too short, otherwise known as truncation mutation.The stop causes Bob's protein to become three amino acids short because the DNA stops. This could cause some major problems for Bob in the future.
• Carol is the most different from Norm. She has 14 differences, creating the lowest percent of similarity. Her DNA is actually really similar to Norm, except that with the fact that she's missing a base, it made everything shift over, creating new codons within the frames. The frame shift has huge consequences on Carol because all of the proteins are different than Norm. This can cause drastic consequences for Carol and her health. 

Interesting Fact: 99% of DNA changes, do not cause problems for the person!

This is pretty interesting actually, I didn't understand that this is how DNA and diseases, etc can play out. I thought it was a lot more complex, but on the surface it doesn't look that difficult. It's crazy how all three of them have a disease risk, just because they're DNA is different.